Cytoglobin function

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WebMay 1, 2002 · Cytoglobin (Cygb) is a low expression hexacoordinate globin found in all tissues of vertebrates [1]. Despite effort to assign a biological role to Cygb, the function of this protein is not... WebMyoglobin is a protein that’s found in your striated muscles, which includes skeletal muscles (the muscles attached to your bones and tendons) and heart muscles. Its main function …

Cytoglobin attenuates pancreatic cancer growth via scavenging …

WebApr 15, 2013 · Cytoglobin (CYGB) is frequently downregulated in many types of human malignancies, and its exogenous overexpression reduces proliferation of cancer cells. Despite its implied tumour suppressor (TSG) functions, its exact role in carcinogenesis remains unclear as CYGB upregulation is also associated with tumour hypoxia and … WebDec 28, 2024 · Cytoglobin (Cygb) was discovered as a novel type of globin that is expressed in mammals; however, its functions remain uncertain. While Cygb protects … can lightning be sile

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WebMay 1, 2002 · Cytoglobin is a hemoprotein widely expressed in fibroblasts and related cell lineages with yet undefined physiological function. Cytoglobin, as other heme proteins, … WebMar 31, 2024 · cytoglobin antioxidant function relied on the same reductive pathway and did not recruit and was not reliant on alternate pathways. The ability of cytoglobin to … WebBackground: Cytoglobin plays cytoprotective roles under hypoxic/ischemic conditions, but the mechanisms remain unclear.Results: Cytoglobin functions as a nitrite reductase leading to NO generation and soluble … can light make you blind

Lipid binding to cytoglobin leads to a change in haem co ... - PubMed

Cytoglobin - an overview ScienceDirect Topics

WebCytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region 17q25, which is frequently lost in multiple malignancies. Previous studies failed to detect evidence for mutations in the CYGB gene. Recent studies provided preliminary evidence for increased ... WebJun 15, 2024 · Toxicology Letters December 15, 2008. Cytoglobin (Cygb) is a recently discovered hexacoordinate globin protein with a yet undefined function. It was found to be up-regulated in toxin-induced liver ... fixative used in histopathologyWebApr 18, 2024 · Although conserved in most vertebrates, the function of cytoglobin is yet unknown. The changes in heme coordination lead to properties not consistent with an oxygen transport role, and a number of functions such as scavenging of reactive oxygen species, nitrite reduction, and nitric oxide dioxygenation have been proposed. fixativspray

"WebNeuroglobin and cytoglobin, members of the globin family, are present in vertebrate cells at very low concentrations. As the function of both proteins is still a matter of debate, it is very important to be able to produce and purify these proteins, and in general all members of the globin family, to homogeneity. " - Cytoglobin function

Cytoglobin function

Characterization of the Mechanism and Magnitude of …

Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or reactive oxygen species, or serve a protective function during oxidative stress. See more Cytoglobin is the protein product of CYGB, a human and mammalian gene. Cytoglobin is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It was discovered in 2001 … See more CYGB expression can be used as a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver. See more • cytoglobin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more • Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K (Jul 2001). "Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells". The Journal of … See more WebOct 3, 2024 · Cytoglobin is a highly conserved redox sensor heme protein with unknown physiological function. Unexpectedly, genetic deletion of zebrafish cytoglobin ( cygb2 ) causes cardiac and...

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WebOct 13, 2024 · Cygb is an oxygen-responsive tissue hemoglobin expressed in distinct regions of thenormoxic and hypoxic brain and may play a key role in the response of the brain to ahypoxic insult. differential expression of cytoglobin argues against a general respiratory function of this molecule, but rather indicates a connective tissue-specific … WebAug 26, 2003 · Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. Cytoglobin is a recently discovered hemeprotein belonging to the globin superfamily together with hemoglobin, myoglobin and neuroglobin. Although distributed in almost all human tissues, cytoglobin has not been ascribed a …

WebSep 9, 2008 · The exact function of CYGB is unknown, although it has been proposed to play a role in collagen synthesis (22, 23), O 2 sensing and transport , or detoxification of … WebApr 10, 2024 · Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates...

WebConclusions: Downregulation of CYGB by the TGF-β1/pSMAD2/SP3-M1 pathway brings about •OH-dependent oxidative DNA damage in activated hepatic stellate cells from patients with NASH. Lay summary: Cytoglobin (CYGB) is a respiratory protein that acts as a scavenger of reactive oxygen species and protects cells from oxidative DNA damage. WebMechanisms of cytoplasmic hemoglobin and myoglobin function Annu Rev Biophys Biophys Chem. 1990;19:217-41. doi: 10.1146/annurev.bb.19.060190.001245. Authors J …

WebCytoglobin consumes NO through its dioxygenase activity, whereby oxycytoglobin (reduced cytoglobin with O2 bound) reacts with NO, resulting in the oxidation of the heme group and formation of nitrate as a byproduct. From: Nitric Oxide (Third Edition), 2024 Related terms: Fibroblast Myoglobin Nitric Oxide Nitrite Reductase Myofibroblast Neuroglobin

WebMay 20, 2013 · Background. Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene. Methods. We immunohistochemically evaluated the expression of Cygb, phosphatidylinositol-3 kinase (PI-3K), phosphorylated (p)-Akt, Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and vascular endothelial growth factor (VEGF) in 88 … can lightning be pinkWebThe globin family includes eight different types of globins, but the best described and characterized in vertebrates are hemoglobin (Hb), myoglobin (Mb), cytoglobin (Cygb), … fixative to keep flowers from drying upWebDec 28, 2024 · Abstract Cytoglobin (Cygb) was discovered as a novel type of globin that is expressed in mammals; however, its functions remain uncertain. While Cygb protects against oxidant stress, the basis for this is unclear, and the effect of Cygb on superoxide metabolism is unknown. fixative used in electron microscopyWebMar 15, 2011 · Cytoglobin is a recently discovered hexa-co-ordinate haemoglobin that does not appear to function as a classical oxygen-binding protein. Its function is unknown and studies on the effects of changes in its expression … fixative used in malarial thick smear:WebCytoglobin (Cgb), a newly discovered member of the vertebrate globin family, binds O 2 reversibly via its heme, as is the case for other mammalian globins (hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb)). While Cgb is expressed in various tissues, its physiological role is not clearly understood. Here, the X-ray crystal structure of wild type … fixativ wellaWebOct 13, 2024 · Cytoglobin has potent superoxide dismutase function. TGF-beta1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma. fixative used that can cause an odor changeWebMay 3, 2024 · Cytoglobin (CYGB), a hemeprotein involved in liver fibrosis and cancer development, is expressed in pericytes of all organs. Here, we examined the role of CYGB in the development of pancreatic cancer. fixative used in eyes