Digoxin kinetics
WebNov 1, 2001 · Pharmacokinetics of digoxin, heart rate and PR ECG interval at rest were assessed. Results Macrogol 4000 coadministration was associated with a 30% decrease of digoxin AUC and a 40% decrease in ... WebOct 1, 2001 · A single digoxin (0.25 mg) dose was given orally to the same group of 10 diurnally active healthy (6 male and 4 female) volunteers in the morning at 08:00 and evening at 20:00 in separate ...
Digoxin kinetics
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WebDigoxin is recommended as adjunctive therapy to angiotensin antagonists, β blockers, and diuretics in select patients with symptomatic heart failure. 1,2 Despite its long history as an agent to treat heart failure, only … WebMar 15, 2010 · The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been …
WebFeb 10, 2024 · In this study, the effect of dose-dependent inhibition of amiodarone on digoxin pharmacokinetics was not clarified. Our Monte Carlo simulation results indicated that 0.25 mg daily of digoxin was an unacceptable dosage because an estimated serum concentration of ≥1.2 ng/mL was predicted to occur in more than half of patients with AF … WebThe serum digoxin concentration: ten questions to ask. Am Fam Physician. 1997 Aug;56(2):495-503, 509-10 Cheng JW, Charland SL, Shaw LM, Kobrin S, Goldfarb S, …
Webdigoxin kinetics and which can be used as a rational basis for dosage regimens in individual patients. Fourhealthy malevolunteersagedbetween27 and 35 years from whom informed consent had been obtained wereusedforthestudy. Testprocedure (i) Oral administration Randomly labelled [H]-digoxin (specific activity 6.4 Ci/mmol) was … WebJan 19, 2024 · National Center for Biotechnology Information
WebApr 1, 2024 · Descriptions. Digoxin is used to treat congestive heart failure, usually in combination with a diuretic (water pill) and an angiotensin-converting enzyme (ACE) inhibitor. It is also used to treat a heart rhythm problem called atrial fibrillation. Digoxin belongs to the class of medicines called digitalis glycosides.
WebApr 1, 2024 · Descriptions. Digoxin is used to treat congestive heart failure, usually in combination with a diuretic (water pill) and an angiotensin-converting enzyme (ACE) … kingman area medicaid dentistsWebDec 3, 2013 · Background—Recent data on digoxin prescribing and adverse events are lacking but could help inform the management of digoxin in contemporary heart failure … kingman arizona airport codeWebJul 2, 2024 · Excretion: Elimination of digoxin follows first-order kinetics (that is, the quantity of digoxin eliminated at any time is propor tional to the total body content). Following intravenous administration to healthy volunteers, 50% to 70% of a digoxin dose is excreted unchanged in the urine. Renal excretion of digoxin is proportional to glomerular ... luxury high rise apartments las vegasWebDigoxin Dosing calculator predicts the percentage of digoxin eliminated in a 24 hour period and the dose of digoxin to maintain therapeutic concentration ... Kramer WG, Lewis RP, … kingman arizona classified adsWebto alter digoxin pharmacokinetics. (7.1) •The potential for drug-drug interactions must be considered prior to and during drug therapy. See full prescribing information. (7.2,7.3, 12.3) USE IN SPECIFIC POPULATIONS ----- •Pregnant patients: It is unknown whether use during pregnancy can cause fetal harm. (8.1) kingman area chamber of commerce kingman azWebDigoxin is a medication used to help treat heart failure and heartbeat irregularities. Your digoxin levels tell you the amount of digoxin that is in your body at a certain time. … kingman arizona framing contractorsWebThe pharmacokinetics of digoxin, the most frequently used digitalis preparation, are reviewed. The dominate serum turnover time is about 34 hours, and is not affected by the route of administration. Excretion is largely as unchanged digoxin in the urine and this excretion is compromised in renal failure. Serum levels of digoxin (determined by ... luxury high rise apartments minneapolis