Phoslactomycins
WebSep 15, 2003 · Phoslactomycins (PLMs) A–F, produced by actinomycetes are polyketide-type antibiotics derived from a hydroxycyclohexanecarboxylic acid or a cyclohexanecarboxylic acid starter unit. Feeding experiments with [2- 13 C]shikimic acid indicated that the C-18 carbon of PLMs comes from C-5 of shikimate. Webbiological activities of phoslactomycins (PLMs) and re-lated compounds (Fig. 1) and the current status of our work on genetic manipulation of the biosynthetic pro-cess. Phoslactomycins represent an unusual structural class of compounds produced by various streptomycetes, containing an a,b-unsaturated d-lactone, an amino
Phoslactomycins
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WebNov 10, 2012 · Phoslactomycins (PLMs) are inhibitors of protein serine/threonine phosphatase 2A showing diverse and important antifungal, antibacterial and antitumor activity. PLMs are polyketide natural products and … WebMay 1, 1999 · In this paper, we examined the effect of phoslactomycins (PLMs) on the regulation of the cytoskeleton of NIH/3T3 fibroblasts. Treatment of cells with PLM-F (10 μM) induced actin filament depolymerization after 4 h. This effect was reversible and actin filaments were reformed 1 h after removal of the inhibitors.
WebLa Biblioteca Virtual en Salud es una colección de fuentes de información científica y técnica en salud organizada y almacenada en formato electrónico en la Región de América Latina y el Caribe, accesible de forma universal en Internet de modo compatible con las bases internacionales. WebPhoslactomycin B C25H40NO8P CID 11497184 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...
WebAbstract. (+)-Phoslactomycin B was synthesized by a highly enantio- and stereoselective approach involving asymmetric pentenylation, Suzuki−Miyaura coupling, ring-closing metathesis, asymmetric dihydroxylation, and Stille coupling. The synthetic method developed enables us to synthesize three other isomers concerning the C11-OH and Δ 12 ... WebJun 12, 2009 · Phoslactomycins (PLMs), biosynthesized using a cyclohexanecarboxylic acid as the starter unit [5], [6], were isolated as antifungal antibiotics [7], [8], [9], [10] (Fig. 1A). Previously, we reported that PLMs are potent Ser/Thr phosphatase 2A (PP2A) inhibitors in vitro and in vivo [11], [12].
WebThe compounds induced quantities of granulocyte CSF (G-CSF) and granulocyte-macrophage CSF (GM-CSF) comparable to those induced by interleukin-1, a strong CSF inducer. These metabolites were called leustroducsins (A, B and C) and were later found to be structurally related to phoslactomycins.
WebNov 10, 2012 · Phoslactomycins (PLMs) are inhibitors of protein serine/threonine phosphatase 2A showing diverse and important antifungal, antibacterial and antitumor … iris candy basketWebFeb 21, 2024 · Phoslactomycins [ 10, 11, 12, 13] and leustroducsins [ 14, 15] are polyketides that possess α,β-unsaturated δ-lactone and cyclohexane moieties at both ends, which are tethered through a highly unsaturated chain with a phosphate ester. pork sirloin in spanishWebA general methodology applicable for the synthesis of the phoslactomycin family of antibiotics, potent and selective protein phosphatase inhibitors, has been developed starting from a β-isocupreidine-catalyzed asymmetric Baylis–Hillman reaction of 3- (4-methoxybenzyloxy)propanal with hexafluoroisopropyl acrylate, and thereby formal … iris canine ckdWebOct 6, 2024 · Phoslactomycins Revisited: Polyketide Tetrahydrofurans and Lactones from an Australian Wasp Nest-Derived Streptomyces sp. CMB-MW079 Angela A. Salim , Kaumadi Samarasekera , Taizong Wu , and … pork sirloin end roast bone-in recipesWebSep 15, 2003 · Phoslactomycins (PLMs) A–F, produced by actinomycetes are polyketide-type antibiotics derived from a hydroxycyclohexanecarboxylic acid or a … pork sirloin roast cooking instructionsWebSep 12, 2003 · Phoslactomycins (PLMs), potent and selective inhibitors of serine threonine phosphatases, are of interest for their antitumor and antiviral activity. Multiple analogs and low titers in the fermentation process have hampered the development of this class of natural products. iris canine glomerulonephritis study groupWebOct 6, 2024 · Phoslactomycins (PLMs) A–F, produced by actinomycetes are polyketide-type antibiotics derived from a hydroxycyclohexanecarboxylic acid or a cyclohexanecarboxylic … pork sirloin roast recipes crock pot